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Träfflista för sökning "WFRF:(Gingnell Malin) ;pers:(Fredrikson Mats);pers:(Motilla Hoppe Johanna)"

Search: WFRF:(Gingnell Malin) > Fredrikson Mats > Motilla Hoppe Johanna

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  • Wlad, Magdalena, et al. (author)
  • Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder
  • 2023
  • In: Behavioural Brain Research. - : Elsevier. - 0166-4328 .- 1872-7549. ; 442
  • Journal article (peer-reviewed)abstract
    • Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT).Methods: Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels.Results: The MSIT activated the dACC as expected but with no differences in task performance or neural reactivity between SAD patients and controls. There were no significant correlations between dACC activity and social or trait anxiety symptom severity. In patients, there was a significant negative correlation between dACC activity and depressive symptoms.Conclusions: In absence of affective challenge, we found no disorder-related cognitive profile in SAD patients since neither MSIT task performance nor dACC neural activity deviated in patients relative to controls.
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